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Related Concept Videos

Blind Procedures02:07

Blind Procedures

Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which child was...
Sleep Apnea01:21

Sleep Apnea

Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...

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Related Experiment Video

Updated: Jun 6, 2026

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
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ACCESS-OSA: a randomized controlled trial for accurate, accessible, and cost-effective screening solutions for

Jack Manners1, Maddy Roch1, Lucia Pinilla1

  • 1Flinders Health and Medical Research Institute: Sleep Health, Flinders University, Bedford Park, SA, Australia.

Sleep Advances : a Journal of the Sleep Research Society
|March 30, 2026
PubMed
Summary

New multi-night home testing for obstructive sleep apnoea (OSA) may improve diagnostic accuracy and cost-effectiveness compared to traditional single-night polysomnography (PSG). This study evaluates these emerging technologies for routine care.

Keywords:
diagnosishealth servicesobstructive sleep apnoeapolysomnographyprecision medicinesleep-disordered breathingupper airway

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Area of Science:

  • Sleep Medicine
  • Diagnostic Technologies
  • Health Economics

Background:

  • Obstructive sleep apnoea (OSA) diagnosis relies on costly, single-night polysomnography (PSG) that may misclassify patients due to night-to-night variability.
  • Emerging multi-night, in-home diagnostic devices offer potential for improved accuracy and accessibility, but require comparative evidence.

Purpose of the Study:

  • To evaluate the diagnostic accuracy and cost-effectiveness of three multi-night in-home devices against single-night PSG for OSA diagnosis.
  • To identify patient and signal characteristics that optimize diagnostic performance of home-based testing.
  • To assess the clinical implementation feasibility of these novel diagnostic pathways.

Main Methods:

  • A three-arm randomized diagnostic strategy trial involving 500 adults with suspected OSA.
  • Participants will undergo both single-night PSG and multi-night assessment using an under-mattress sensor, oximetry ring, and forehead EEG device.
  • Randomization to different interpretation pathways, with sequential diagnostic decisions and a blinded expert panel for consensus diagnosis.

Main Results:

  • The primary outcome is the diagnostic accuracy of each multi-night pathway compared to the consensus diagnosis.
  • Secondary outcomes include cost-effectiveness, patient acceptability, clinical confidence, and long-term health and quality of life.
  • Analysis will determine if simplified, accessible multi-night testing enhances OSA diagnosis in routine care.

Conclusions:

  • This study aims to provide definitive evidence on the utility of multi-night home testing for obstructive sleep apnoea.
  • Findings will guide the adoption of more accurate, cost-effective, and patient-centered diagnostic strategies for OSA.
  • The research will inform clinical practice and healthcare policy regarding sleep disorder diagnosis.