Steroid-Induced Takotsubo Cardiomyopathy in a Patient With Immune Thrombocytopenic Purpura

This case report highlights a temporal relationship between dexamethasone administration and the onset of Takotsubo cardiomyopathy, underscoring the importance of recognizing pharmacologic agents as potential non-traditional triggers, particularly in patients with underlying cardiovascular disease and no identifiable emotional or physical stressors. Diagnosis favored a dexamethasone-triggered Takotsubo phenotype based on non-obstructive coronaries, regional wall-motion abnormalities extending beyond a single arterial territory, absence of alternate stressors, and biologic plausibility of steroid-mediated catecholaminergic upregulation.