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Updated: Mar 31, 2026

Evaluation of Substrate Ubiquitylation by E3 Ubiquitin-ligase in Mammalian Cell Lysates
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Targeting ubiquitin-specific peptidase 22 in solid tumours: from ubiquitination to immunotherapy

Zhe Li1, Liming Wang2, Jingyi Liu3

  • 1Department of Anesthesiology, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.

Frontiers in Cell and Developmental Biology
|March 30, 2026
PubMed

Insights

Ubiquitin-specific peptidase 22 (USP22) is crucial in tumour biology and immune regulation. Understanding its molecular network offers new therapeutic strategies for cancer and immunotherapy.

Area of Science:

  • Oncology
  • Immunology
  • Biochemistry

Background:

  • Ubiquitin-specific peptidase 22 (USP22) is a deubiquitinating enzyme with emerging roles in cancer.
  • The precise regulatory mechanisms of USP22 in tumourigenesis are not fully understood.
  • USP22 plays a significant role in immune regulation, impacting clinical treatment and immunotherapy.

Purpose of the Study:

  • To review and summarize the regulatory mechanisms of USP22 in tumour biology.
  • To analyze the critical role of USP22 in immune regulation within the tumour microenvironment.
  • To provide insights into novel therapeutic strategies targeting USP22 for cancer treatment and immunotherapy.

Main Methods:

  • Literature review and synthesis of existing research on USP22.
  • Analysis of USP22's molecular functions in various tumour types.
  • Examination of USP22's impact on immune cell function and anti-tumour immunity.

Main Results:

  • USP22 influences multiple tumour biological processes, including proliferation, migration, and invasion.
  • USP22 modulates immune cell function and the tumour immune microenvironment.
  • The molecular regulatory network of USP22 is complex and varies across different cancers.

Conclusions:

  • USP22 is a key regulator of tumour biology and immune responses.
  • Targeting USP22 presents a promising strategy for enhancing cancer therapy and immunotherapy.
  • Further elucidation of USP22's molecular network is essential for developing effective treatments.
Keywords:
ICBsUSP22clinical treatmentimmune responsemetabolism

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