Related Experiment Video

Updated: Mar 31, 2026

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
10:06

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

Published on: April 26, 2017

9.5K

Harnessing CRISPR-dCas13Rx to identify novel antisense targets for therapeutic splicing modulation

Ravindra N Singh1, Christiano R R Alves2

  • 1Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA.

Molecular Therapy. Nucleic Acids
|March 30, 2026
PubMed
Abstract

No abstract available in PubMed .

More Related Videos

CIRCLE-Seq for Interrogation of Off-Target Gene Editing
08:23

CIRCLE-Seq for Interrogation of Off-Target Gene Editing

Published on: November 1, 2024

1.8K
Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

1.3K

Related Experiment Videos

Last Updated: Mar 31, 2026

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
10:06

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

Published on: April 26, 2017

9.5K
CIRCLE-Seq for Interrogation of Off-Target Gene Editing
08:23

CIRCLE-Seq for Interrogation of Off-Target Gene Editing

Published on: November 1, 2024

1.8K
Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

1.3K

Related Concept Videos

CRISPR01:59

CRISPR

59.1K
Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
59.1K
CRISPR01:59

CRISPR

18.9K
18.9K
CRISPR/Cas9 Genome Editing01:28

CRISPR/Cas9 Genome Editing

2.6K
The CRISPR-Cas system serves as a bacterial defense mechanism against invading genetic elements such as viruses and plasmids, forming the foundation for its adaptation as a powerful genome-editing tool. Originally discovered in prokaryotes, this system has been repurposed to revolutionize genetic engineering across a wide range of organisms, including plants, animals, and humans. The core component, Cas9, is an endonuclease derived from Streptococcus pyogenes, capable of introducing...
2.6K

Articles linked to this work by shared authors, journal, and citation graph.

Managing nusinersen therapy during pregnancy in spinal muscular atrophy type 3.

BMJ case reports·2026

Nusinersen: the antisense oligonucleotide at the forefront of spinal muscular atrophy treatment.

RNA biology·2026

Statins and genetic inhibition of the mevalonate pathway activate an ATF3-STMN2 regenerative program.

bioRxiv : the preprint server for biology·2026

Cardiac defects in spinal muscular atrophy and the role of SMN in cardiomyocyte homeostasis.

bioRxiv : the preprint server for biology·2026

Environmental impact, cost, and acceptability of a laboratory sustainability certification program for biomedical research in an academic medical center.

The journal of climate change and health·2026

Circulating Tau Profiles in Pediatric and Adult Patients with Spinal Muscular Atrophy.

medRxiv : the preprint server for health sciences·2026

SafeSense: An open-access safety atlas for antisense oligonucleotides adverse events in human.

Molecular therapy. Nucleic acids·2026

Fast activity prediction of chemically modified siRNAs via structure-based energy calculations and inference-augmented tabular deep learning.

Molecular therapy. Nucleic acids·2026

Polyamines are i-motif disruptors.

Molecular therapy. Nucleic acids·2026

A scalable platform for dumbbell siRNA production using engineered Td PIE in probiotic E. coli.

Molecular therapy. Nucleic acids·2026

Antisense peptide nucleic acids targeting ribosomal protein genes: A novel strategy against carbapenem-resistant Acinetobacter baumannii.

Molecular therapy. Nucleic acids·2026

Targeted FcRn to deliver epitope-optimized RBD confers broad-spectrum mucosal protection against SARS-CoV-2.

Molecular therapy. Nucleic acids·2026

Insight into what IP346 measures through characterization of MOAH distribution in DMSO and organic phase by comprehensive two-dimensional gas chromatography.

Food research international (Ottawa, Ont.)·2026

Evaluation of Citicoline-loaded Lutrol 127/Carbopol/Hyaluronic acid-based gels for brain delivery by intranasal administration.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·2026

Metabolic engineering of Taxus chinensis suspension cell lines for overproduction of paclitaxel reveals insights into pathway regulation.

Metabolic engineering·2026

Establishment of a CRISPR/Cas9-mediated system for targeted editing of the MFS gene in mint.

Plant cell reports·2026

Structural and functional analysis of peptidyl-tRNA hydrolase 2 from Candidatus Lokiarchaeum sp. GC14_75.

Acta crystallographica. Section F, Structural biology communications·2026

Inhalable Spray-Dried Carriers for Deep Lung Delivery and In Situ Synthesis of Allicin.

ACS omega·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
Jove
Visualize
Contact Us