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Updated: Jun 22, 2026

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture

Published on: April 8, 2016

Spatial transcriptomic profiling reveals body site-specific inflammatory differences in psoriasis lesions.

Thomas Emmanuel^1,2, Hakim Ben Abdallah^1,2, Morten Muhlig Nielsen³

¹Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark.

Frontiers in Immunology

|March 30, 2026

Summary

This summary is machine-generated.

Psoriasis treatment resistance varies by body site. Spatial transcriptomics reveal distinct molecular signatures in lesions, particularly involving IL-23 and IL-17 signaling, offering targets for site-specific therapies.

Keywords:

RNA sequencing immunohistochemistry psoriasis spatial transcriptomics treatment-resistance

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Area of Science:

Dermatology
Immunology
Genomics

Background:

Psoriasis is a chronic inflammatory skin condition with variable treatment response.
Lesions on the scalp and lower extremities are often resistant to treatment.
Understanding site-specific differences in psoriasis is crucial for targeted therapies.

Purpose of the Study:

To investigate histologic and spatial transcriptomic variations in psoriasis lesions across different anatomical locations.
To determine if these differences correlate with treatment resistance in specific body sites.
To identify potential targets for site-specific psoriasis treatment strategies.

Main Methods:

Quantitative immunohistochemistry and transcriptomic digital spatial profiling were performed on psoriasis skin biopsies from 12 patients.
Biopsies were collected from unaffected trunk skin and lesional skin (LS) of the scalp, upper extremity, and lower extremity.
Histological analysis assessed epidermal thickness, while immunohistochemistry and RNA profiling examined molecular markers and gene expression.

Main Results:

No significant differences in epidermal thickness or immunohistochemical markers were observed between lesional skin sites.
Spatial RNA profiling revealed significant site-specific transcriptomic differences in psoriasis lesions.
Interleukin-23 (IL-23) signaling was enriched in lower extremity epidermis, and IL-17 signaling was more pronounced in lesional skin samples.

Conclusions:

Psoriasis exhibits minimal histological variation but significant transcriptomic and pathway differences across anatomical locations.
These site-specific molecular profiles suggest potential for developing targeted therapeutic strategies.
Further research into these differences may improve treatment outcomes for resistant psoriasis plaques.