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Interleukin-24 in type 2 immune diseases
Xiaoting Song1, Dong Lan2, Fang Liu1
1Department of Dermatology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Frontiers in Immunology
|March 30, 2026
Summary
Interleukin-24 (IL-24) plays a role in type 2 immune diseases. This review summarizes IL-24
Area of Science:
- Immunology
- Molecular Biology
- Dermatology
Background:
- Interleukin-24 (IL-24) is a cytokine from the IL-20 family, produced by various immune and non-immune cells.
- IL-24 signaling influences cell growth, fate, death, and inflammation, with context-dependent effects in disease.
Purpose of the Study:
- To review recent advancements in IL-24 characterization.
- To explore the pathogenic roles of IL-24 in type 2 immune diseases.
- To highlight IL-24's potential as a therapeutic target or biomarker.
Main Methods:
- Literature review of existing studies on IL-24.
- Analysis of IL-24's function in various disease contexts.
- Synthesis of current knowledge on IL-24's involvement in type 2 immunity.
Main Results:
- IL-24 is implicated in the pathogenesis of several type 2 immune diseases.
- Specific roles of IL-24 vary depending on the disease and cellular context.
- Emerging evidence links IL-24 to chronic spontaneous urticaria, atopic dermatitis, and allergic airway diseases.
Conclusions:
- IL-24 is a significant factor in type 2 immune disease development.
- Further research into IL-24 pathways could lead to novel therapeutic strategies.
- IL-24 may serve as a valuable biomarker for diagnosing and monitoring these conditions.
