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T Cell Types and Functions

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

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Related Experiment Video

Updated: Mar 31, 2026

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226

Published on: May 10, 2022

Interleukin-24 in type 2 immune diseases.

Xiaoting Song¹, Dong Lan², Fang Liu¹

¹Department of Dermatology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

Frontiers in Immunology

|March 30, 2026

Summary

Interleukin-24 (IL-24) plays a role in type 2 immune diseases. This review summarizes IL-24

Keywords:

IL-24 cytokine JAK - STAT signaling pathway atopic allergic diseases targeted therapy type 2 immune diseases

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Last Updated: Mar 31, 2026

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Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment

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Published on: June 24, 2020

Area of Science:

Immunology
Molecular Biology
Dermatology

Background:

Interleukin-24 (IL-24) is a cytokine from the IL-20 family, produced by various immune and non-immune cells.
IL-24 signaling influences cell growth, fate, death, and inflammation, with context-dependent effects in disease.

Purpose of the Study:

To review recent advancements in IL-24 characterization.
To explore the pathogenic roles of IL-24 in type 2 immune diseases.
To highlight IL-24's potential as a therapeutic target or biomarker.

Main Methods:

Literature review of existing studies on IL-24.
Analysis of IL-24's function in various disease contexts.
Synthesis of current knowledge on IL-24's involvement in type 2 immunity.

Main Results:

IL-24 is implicated in the pathogenesis of several type 2 immune diseases.
Specific roles of IL-24 vary depending on the disease and cellular context.
Emerging evidence links IL-24 to chronic spontaneous urticaria, atopic dermatitis, and allergic airway diseases.

Conclusions:

IL-24 is a significant factor in type 2 immune disease development.
Further research into IL-24 pathways could lead to novel therapeutic strategies.
IL-24 may serve as a valuable biomarker for diagnosing and monitoring these conditions.