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Microbial Corrosion01:24

Microbial Corrosion

Microbiologically Influenced Corrosion (MIC) is a significant form of material degradation caused by the metabolic activities of microorganisms. This phenomenon poses substantial challenges across various industries, including oil and gas, maritime, and water treatment sectors.MIC occurs when microorganisms, such as bacteria, archaea, and fungi, colonize metal surfaces, forming biofilms that alter the local electrochemical environment. These biofilms can lead to the production of corrosive...

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Multivalent sulphur-modified biosilica nanostructures for bacterial enteritis therapy.

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New nanostructures combat bacterial enteritis by eradicating pathogens and reducing inflammation. This novel approach utilizes sulfur-modified silica nanoparticles for targeted delivery of antibacterial agents, offering a promising therapy for gut infections.

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Microbiology

Background:

  • Bacterial enteritis disrupts gut microbiota and causes inflammation.
  • Pathogenic bacteria pose a significant threat to gastrointestinal health.
  • Current treatments have limitations in efficacy and side effects.

Purpose of the Study:

  • To develop novel polyethyleneimine (PEI)-based mesoporous silica nanostructures for treating bacterial enteritis.
  • To simultaneously eradicate pathogenic bacteria, modulate immune response, and reduce intestinal inflammation.
  • To create a versatile platform for targeted delivery of antibacterial agents.

Main Methods:

  • Synthesized PEI-based mesoporous silica nanostructures co-modified with -SH and -S-S- groups.
  • Investigated the mechanism of bacterial eradication via glutathione balance perturbation and ROS scavenging.
  • Evaluated the absorption of bacterial components (LPS, flagella, cfDNA) by the nanostructures.
  • Assessed the encapsulation and targeted delivery of antibacterial agents (berberine chloride, norfloxacin).

Main Results:

  • The nanostructures effectively eradicated pathogenic bacteria by disrupting their redox balance.
  • Sulfur modification (-SH, -S-S-) scavenged reactive oxygen species, mitigating inflammation.
  • PEI-modified silica efficiently absorbed bacterial toxins and extracellular DNA.
  • Encapsulated antibacterial agents were delivered effectively, reducing side effects.

Conclusions:

  • PEI-based mesoporous silica nanostructures offer a multifunctional strategy for bacterial enteritis.
  • The sulfur modification enhances antibacterial activity and anti-inflammatory effects.
  • This platform shows potential for next-generation antimicrobial therapies with targeted drug delivery.