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Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility

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Engineering Peptide-Based Hydrogels: Smart Therapeutic Platforms for Inflammatory Disorders.

Tanni Dam¹, Priyanka Sharma¹, Pawni Kaur²

¹Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab 140401, India.

ACS Biomaterials Science & Engineering

|March 30, 2026

Summary

Peptide-based hydrogels offer a promising new approach for treating chronic inflammatory diseases by delivering anti-inflammatory therapies precisely. These adaptable systems can modulate the immune system and promote tissue regeneration, overcoming limitations of current treatments.

Keywords:

hydrogels inflammatory disorders neuroinflammation peptide stimuli-responsive

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Area of Science:

Biomaterials Science
Drug Delivery
Immunology

Background:

Chronic inflammatory diseases present a significant global health challenge with limited effective treatments.
Conventional therapies offer symptomatic relief but have adverse effects and diminishing efficacy over time.

Purpose of the Study:

To review the design, stimulus-responsive behavior, and therapeutic applications of peptide-based hydrogels for chronic inflammatory diseases.
To highlight their potential for targeted drug delivery, immunomodulation, and tissue regeneration.

Main Methods:

Review of current literature on peptide-based hydrogels for anti-inflammatory applications.
Analysis of design considerations and stimuli-responsive properties.
Evaluation of hydrogel platforms for encapsulating and delivering anti-inflammatory agents.

Main Results:

Peptide-based hydrogels demonstrate tunable physicochemical properties and biocompatibility.
These hydrogels can be designed as stimuli-responsive systems for targeted drug delivery.
Encapsulation of anti-inflammatory agents facilitates localized immunomodulation and tissue regeneration.

Conclusions:

Peptide-based hydrogels represent adaptable and effective platforms for treating chronic inflammatory diseases.
They offer precise, localized delivery of anti-inflammatory therapies, promoting tissue repair.
Further research into overcoming translational obstacles is crucial for clinical development.