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IL-18 on the rise: tracking inflammatory drift in hemodialysis patients - a pilot study
Jessyca Sousa de Brito1, Hugo de Luca Corrêa2,3, Thiago Santos Rosa2,3,4
1Universidade Federal do Rio de Janeiro, Programa de Pós-Graduação em Ciências Biológicas (Fisiologia), Rio de Janeiro, RJ, Brazil.
Introduction:
Interleukin-18 (IL-18) is a pro-inflammatory cytokine associated with inflammaging and cellular senescence in chronic kidney disease (CKD).
Objective:
To evaluate longitudinal changes in plasma IL-18 levels in incident hemodialysis (HD) patients.
Methods:
An observational longitudinal study was conducted, with blood and anthropometric data collected at baseline, 6, and 12 months. IL-18 was measured by ELISA, and biochemical parameters were measured using Bioclin® kits.
Results:
Twenty-four patients (61.4 ± 3.5 years) were enrolled; 10 and 5 completed the 6- and 12-month assessments, respectively. IL-18 levels increased significantly at 6 months (p = 0.04) and at 12 months (p = 0.01) versus baseline and correlated positively with creatinine (r = 0.893; p = 0.04) and urea (r = 0.823; p = 0.05).
Conclusion:
In this pilot study with incident HD patients, plasma IL-18 increased over one year of treatment and was associated with uremia-related markers.
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