Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Mar 31, 2026

Tuning the Contractility and Deformation Modes of Active Actin-Based Assemblies In Vitro: From Two-Dimensional Active Networks to Liquid Crystal Drops
06:48

Tuning the Contractility and Deformation Modes of Active Actin-Based Assemblies In Vitro: From Two-Dimensional Active Networks to Liquid Crystal Drops

Published on: July 11, 2025

1.0K

Activity-driven swelling and dynamics in segmentally active Rouse chains.

Koushik Goswami1, Norman Hsia2, Cheng-Hung Chang1,3

  • 1Physics Division, National Center for Theoretical Sciences, National Taiwan University, Taipei 106319, Taiwan.

The Journal of Chemical Physics
|March 30, 2026
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

Cell Motility through Blebbing01:16

Cell Motility through Blebbing

2.7K
Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
Blebbing Through the Matrix
In multicellular...
2.7K
Motor Unit Stimulation01:20

Motor Unit Stimulation

4.8K
When the neuron of a motor unit fires an action potential, it triggers a series of events, leading to a twitch contraction in the muscle fibers. The process of excitation-contraction coupling is crucial in relaying the action potential to the muscle fibers.
The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...
4.8K
Radical Chain-Growth Polymerization: Chain Branching01:17

Radical Chain-Growth Polymerization: Chain Branching

2.6K
The skeletal structure of polymers synthesized via radical polymerization is always branched. For example, the polymerization of ethylene by radical polymerization results in a low-density grade of polyethylene with a heavily branched skeletal structure. Here, the radical site abstracts hydrogen from the growing chain, and the radical site shifts from the end (a primary carbon center) to anywhere within the growing chain (a secondary carbon center). Consequently, the part of the chain from the...
2.6K
Mechanism of Lamellipodia Formation01:31

Mechanism of Lamellipodia Formation

4.0K
Cells migrating in response to external stimuli form lamellipodia, which are thin membrane protrusions supported by a mesh of linked, branched, or unbranched actin filaments. These actin filaments interact with myosin motor proteins, creating the dynamic actomyosin complex within the cytoskeleton. Contractility, or the ability to generate contractile stress, is inherent to the actomyosin complex. It helps cells detect the stiffness of the surrounding ECM and exert contractile force for...
4.0K
Muscle Stimulation Frequency01:22

Muscle Stimulation Frequency

5.1K
The contraction strength of muscles is regulated by motor neurons, which modulate the frequency of action potentials dispatched to the motor units based on the body's requirements. This process of varying the muscle stimulation frequency allows muscles to contract with a force that is precisely tailored to the needs of the moment, whether lifting a feather or a heavy box.
Wave summation
At low firing rates, motor neurons induce individual twitch contractions in muscle fibers. These twitches...
5.1K
Excitation-Contraction Coupling in Skeletal Muscles01:20

Excitation-Contraction Coupling in Skeletal Muscles

19.9K
Excitation-contraction coupling is a series of events that occur between generating an action potential and initiating a muscle contraction. It occurs at the triad, a structure found in skeletal muscle fibers that comprise a T-tubule and terminal cisternae of the sarcoplasmic reticulum on each side. These triads are visible in longitudinally sectioned muscle fibers. They are typically located at the A-I junction — the junction between the A and I bands of the sarcomere.
When an action...
19.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Boundary aggregation of rod-shaped active agents.

Soft matter·2026
Same author

Trapped tracer in a non-equilibrium bath: dynamics and energetics.

Soft matter·2023
Same author

Roadmap on biology in time varying environments.

Physical biology·2021
Same journal

Anharmonic phonons via quantum thermal bath simulations.

The Journal of chemical physics·2026
Same journal

Quantum simulation of alignment dependent differential cross sections in co-propagating molecular beams at cold collision energies.

The Journal of chemical physics·2026
Same journal

Non-additive ion effects on the coil-globule equilibrium of a generic polymer in aqueous salt solutions.

The Journal of chemical physics·2026
Same journal

Insights into the unexpected small reduction of the temperature of maximum density of water by lithium chloride addition.

The Journal of chemical physics·2026
Same journal

Optical frequency comb double-resonance spectroscopy of the 9030-9175 cm-1 states of ethylene.

The Journal of chemical physics·2026
Same journal

Time reversal breaking of colloidal particles in cells.

The Journal of chemical physics·2026
See all related articles

Localized activity in Rouse chains causes unusual swelling patterns. Placing the active segment near chain ends enhances swelling more than midchain positioning, impacting polymer conformation and dynamics.

Area of Science:

  • Polymer Physics
  • Soft Matter Physics
  • Biophysics

Background:

  • Understanding the behavior of active polymers is crucial for various applications.
  • Heterogeneous activity within polymer chains presents complex conformational and dynamic challenges.
  • The Rouse chain model provides a foundational framework for polymer dynamics.

Purpose of the Study:

  • To investigate how localized activity in a segmentally active Rouse chain influences its conformation and dynamics.
  • To quantify the effects of active segment length and position on polymer behavior.
  • To develop a tractable theoretical framework for heterogeneous polymer activity.

Main Methods:

  • Analytical normal-mode theory applied to active Rouse chains.
  • Brownian-dynamics simulations to model polymer behavior.

More Related Videos

Cardiac Muscle Cell-based Actuator and Self-stabilizing Biorobot - Part 2
09:33

Cardiac Muscle Cell-based Actuator and Self-stabilizing Biorobot - Part 2

Published on: May 9, 2017

9.2K
Activity of Posterior Lateral Line Afferent Neurons during Swimming in Zebrafish
10:34

Activity of Posterior Lateral Line Afferent Neurons during Swimming in Zebrafish

Published on: February 10, 2021

4.3K

Related Experiment Videos

Last Updated: Mar 31, 2026

Tuning the Contractility and Deformation Modes of Active Actin-Based Assemblies In Vitro: From Two-Dimensional Active Networks to Liquid Crystal Drops
06:48

Tuning the Contractility and Deformation Modes of Active Actin-Based Assemblies In Vitro: From Two-Dimensional Active Networks to Liquid Crystal Drops

Published on: July 11, 2025

1.0K
Cardiac Muscle Cell-based Actuator and Self-stabilizing Biorobot - Part 2
09:33

Cardiac Muscle Cell-based Actuator and Self-stabilizing Biorobot - Part 2

Published on: May 9, 2017

9.2K
Activity of Posterior Lateral Line Afferent Neurons during Swimming in Zebrafish
10:34

Activity of Posterior Lateral Line Afferent Neurons during Swimming in Zebrafish

Published on: February 10, 2021

4.3K
  • Analysis of global conformational measures (radius of gyration, end-to-end distance).

    • Main Results:

    • Localized activity induces an unusual swelling pattern, with end-positioned active segments causing greater swelling than midchain segments.
    • Fluctuations depend on active segment location, size, and overlap with observation windows.
    • A tagged point within the active region shows distinct diffusive-subdiffusive-superdiffusive crossovers.

    Conclusions:

    • Segmental activity in Rouse chains leads to position-dependent conformational changes and complex dynamics.
    • The findings offer a minimal, analytically tractable model for understanding heterogeneous activity in polymers.
    • This framework can aid in interpreting experimental data on active biopolymers.