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The Inflammatory Basis of Acne Pathogenesis.
Shuang Han1, Zonghuang Ding1, Junfeng Zheng2
1The First College of Clinical Medical Science, China Three Gorges University, Yichang Central People's Hospital, Yichang, China.
Dermatology (Basel, Switzerland)
|March 30, 2026
Summary
This review explores how inflammation, driven by genetics and factors like Cutibacterium acnes, causes acne. Understanding these inflammatory pathways offers new avenues for acne prevention and treatment.
Area of Science:
- Dermatology
- Immunology
- Genetics
Background:
- Acne is a common inflammatory and hereditary skin disorder.
- Genetic predisposition and persistent local inflammation are key to acne pathogenesis.
- Cutibacterium acnes infection and dysregulated signaling pathways contribute to chronic inflammation.
Purpose of the Study:
- To systematically review and analyze the role of inflammation in acne development.
- To elucidate cellular, molecular, and genetic mechanisms underlying acne pathogenesis.
- To provide insights for novel acne prevention and treatment strategies.
Main Methods:
- Systematic review and analysis of existing literature.
- Examination of cellular and molecular inflammatory processes.
- Investigation of genetic factors and signaling pathways in acne.
Main Results:
- Genetic factors significantly influence acne development.
- Inflammatory pathways involving Toll-like receptors, NLRP3 inflammasome, IL-6/STAT3, and Notch signaling are crucial.
- Inflammatory cytokines and immune responses are activated, leading to acne lesions.
Conclusions:
- Inflammation is central to acne pathogenesis at multiple levels.
- Understanding these inflammatory mechanisms is vital for developing effective acne treatments.
- Targeting specific inflammatory pathways may offer new therapeutic approaches for acne.
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