Maxillary odontogenic myxoma: diagnostic and therapeutic insights of two case reports with management algorithm

To describe the clinical presentation, surgical management, and reconstruction of maxillary odontogenic myxomas through two case reports, and to propose a comprehensive management algorithm to guide diagnosis and treatment decisions.

This study reports two cases treated at Piñero Hospital with resection and reconstruction using temporalis muscle flaps. Diagnosis was confirmed by clinical, radiological, and histopathological examinations. The first case involved a 36-year-old female with a multilobulated osteolytic lesion in the upper jaw; follow-up at 27 months showed no recurrence. The second case, a 27-year-old male, presented a large, aggressive osteolytic lesion; 32-month follow-up demonstrated successful healing without relapse.

Maxillary odontogenic myxomas require individualized, multidisciplinary management. The proposed algorithm, integrating tumor size, extension, surgical approaches, and reconstruction options, offers a practical decision-making tool to improve clinical outcomes.