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Related Experiment Video

Updated: Apr 1, 2026

A Novel Stretching Platform for Applications in Cell and Tissue Mechanobiology
16:46

A Novel Stretching Platform for Applications in Cell and Tissue Mechanobiology

Published on: June 3, 2014

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A Novel Platform for In Vitro Cellular Stretching and Imaging.

Benjamin M Goykadosh1, Suzanne E Stasiak1, Vasuretha Chandar1

  • 1Department of Bioengineering, Northeastern University.

Journal of Visualized Experiments : Jove
|March 30, 2026
PubMed
Summary
This summary is machine-generated.

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Researchers developed a new microscope-compatible cell stretcher to study how mechanical forces, like extracellular matrix (ECM) stiffness and strain, affect cell behavior. This tool aids in understanding diseases such as cancer and asthma.

Area of Science:

  • Cell Biology
  • Biophysics
  • Biomaterials Science

Background:

  • Cells sense and respond to mechanical cues (e.g., extracellular matrix stiffness, cyclic strain).
  • Dysregulation of cellular mechanical forces contributes to diseases like asthma, hypertension, and cancer.
  • Existing in-vitro stretching devices have limitations in physiological relevance and imaging compatibility.

Purpose of the Study:

  • To develop a versatile, microscope-compatible cell stretcher for applying controlled mechanical strain.
  • To enable independent modulation of substrate stiffness and extracellular matrix composition.
  • To investigate cellular responses to mechanical cues in physiological and pathological contexts.

Main Methods:

  • A compact, microscope-compatible stretcher device applying isotropic or uniaxial strain to adherent cells.

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Equibiaxial Stretching Device for High Magnification Live-Cell Confocal Fluorescence Microscopy
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Equibiaxial Stretching Device for High Magnification Live-Cell Confocal Fluorescence Microscopy

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Related Experiment Videos

Last Updated: Apr 1, 2026

A Novel Stretching Platform for Applications in Cell and Tissue Mechanobiology
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A Novel Stretching Platform for Applications in Cell and Tissue Mechanobiology

Published on: June 3, 2014

12.4K
Live Cell Imaging during Mechanical Stretch
07:42

Live Cell Imaging during Mechanical Stretch

Published on: August 19, 2015

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Equibiaxial Stretching Device for High Magnification Live-Cell Confocal Fluorescence Microscopy
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Equibiaxial Stretching Device for High Magnification Live-Cell Confocal Fluorescence Microscopy

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  • Elastomeric culture dishes with tunable Young's modulus and customizable matrix protein coatings.
  • Stepper motor-driven design for programmable cyclic waveform generation.
  • Quantification of intracellular calcium dynamics and cell traction forces.

    • Main Results:

    • Demonstrated the device's capability to apply controlled mechanical stretch to cells.
    • Successfully quantified cellular responses, including calcium dynamics and traction forces.
    • Validated the platform's utility with primary human airway smooth muscle cells.

    Conclusions:

    • The developed cell stretcher is a versatile tool for studying the impact of mechanical cues on cellular function.
    • This platform facilitates research into the role of mechanical forces in both healthy and diseased states.
    • Enables independent control over substrate stiffness and extracellular matrix properties for advanced cell mechanobiology studies.