Structural characterization and biological activities of specialized metabolites from mangrove-derived fungi Aspergillus sp
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Published on: March 15, 2012
Jiajia Liu1, Yue Zeng1, Xinxu Ge2
1Department of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China; Experimental Medicine Center, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China; Metabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou, Sichuan, China.
Abstract:
The mangrove ecosystem is a complex ecosystem that supports a wide variety of microorganisms, among which fungi represent one of the largest groups. Aspergillus fungi constitute the dominant component, and these mangrove-derived Aspergillus strains can produce a wealth of specialized metabolites with unique chemical structures and diverse biological activities. In this paper, a total of 346 specialized metabolites isolated from mangrove-derived Aspergillus species over the past five years (January 2020-April 2025) are summarized. These compounds are classified into five major categories: polyketides, terpenoids, alkaloids, peptides, and other types. A total of 134 compounds exhibited biological activities, including anti-inflammatory, cytotoxic, antibacterial, and α-glucosidase-inhibitory activities, among which 20 compounds displayed multiple biological activities. These specialized metabolites, which possess unique structures and notable bioactivities, serve as a reference for the development and innovation of new pharmaceuticals.
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