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Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
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Activity-Based Functional Exercise for Disability in Systemic Sclerosis: Protocol for a Feasibility Randomised

Gabriela da Silva Santos1, André Nunes Soares1, Geisielly Maria Porto Soares1

  • 1Department of Physical Therapy, Federal University of Pernambuco, Recife, Brazil.

Musculoskeletal Care
|March 30, 2026
PubMed
Summary
This summary is machine-generated.

This study assesses a new functional exercise program for Systemic Sclerosis (SSc) patients to improve global disability. Early results show promising eligibility and ongoing recruitment for this innovative intervention.

Keywords:
exercisefeasibility studiesfunctional statusphysical therapyquality of lifesystemic sclerosis

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Area of Science:

  • Rheumatology
  • Rehabilitation Medicine
  • Clinical Trial Design

Background:

  • Systemic Sclerosis (SSc) significantly impacts patient quality of life and functional capacity.
  • Current exercise interventions for SSc often target isolated body parts, not addressing overall disability.
  • A need exists for comprehensive, functional activity-based exercise programs to manage SSc-related disability.

Purpose of the Study:

  • To evaluate the feasibility of a functional activity-based exercise program for individuals with Systemic Sclerosis.
  • To assess the potential of this program to address global disability in SSc patients.
  • To gather preliminary data for refining a larger clinical trial.

Main Methods:

  • A randomized controlled mixed-methods feasibility trial involving SSc patients (aged 18-65, SHAQ score ≥1).
  • Participants assigned to a control group (educational booklet) or intervention group (booklet + 10-week supervised functional exercise).
  • Feasibility outcomes: recruitment, retention, adherence, safety. Clinical outcomes: disability, function, fatigue, mental health.

Main Results:

  • The study is in its early stages with ongoing recruitment.
  • Preliminary eligibility assessment indicates a high proportion (83.6%) of registered patients are potentially eligible.
  • Recruitment and feasibility data collection are actively in progress.

Conclusions:

  • The proposed functional exercise protocol offers an innovative and cost-effective approach for SSc management.
  • Findings will inform the design of a more robust clinical trial.
  • Potential logistical and disease-specific challenges are acknowledged but do not preclude further investigation.