Related Experiment Video
Updated: Apr 1, 2026
An Immunocompetent Murine Model for Laser Interstitial Thermal Therapy of Glioblastoma
Published on: November 15, 2024
MR-Guided Laser Interstitial Thermal Therapy for Recurrent Glioblastoma: A Case Report With Novel Insights Into
Silas Haahr Nielsen1,2, Sara Blaabjerg Artzi2,3,4,5, Jane Skjøth-Rasmussen1,2,5
1Department of Neurosurgery, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Abstract:
MR-guided laser interstitial thermal therapy (LITT) offers a minimally invasive option for recurrent glioblastoma, but human post-treatment tissue data are scarce. In this case report, post-LITT tissue exhibited distinct zonal changes, including central necrosis within the ablation zone and reduced tumour proliferation with increased CD8+ T-cell infiltration in the perilesional transition zone, suggesting that LITT may influence the local immune landscape in recurrent glioblastoma.
