Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

41.1K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
41.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Novel Counteraction Effect of H<sub>2</sub>O and SO<sub>2</sub> toward HCl on the Chemical Adsorption of Gaseous Hg<sup>0</sup> onto Sulfureted HPW/γ-Fe<sub>2</sub>O<sub>3</sub> at Low Temperatures: Mechanism and Its Application in Hg<sup>0</sup> Recovery from Coal-Fired Flue Gas.

Environmental science & technology·2021
Same author

An Early-Onset Advanced Rectal Cancer Patient With Increased KRAS Gene Copy Number Showed A Primary Resistance to Cetuximab in Combination With Chemotherapy: A Case Report.

Frontiers in oncology·2021
Same author

Construction of a risk assessment model of cardiovascular disease in a rural Chinese hypertensive population based on lasso-Cox analysis.

Journal of clinical hypertension (Greenwich, Conn.)·2021
Same author

Low fat mass index outperforms handgrip weakness and GLIM-defined malnutrition in predicting cancer survival: Derivation of cutoff values and joint analysis in an observational cohort.

Clinical nutrition (Edinburgh, Scotland)·2021
Same author

Development and validation of a Modified Patient-Generated Subjective Global Assessment as a nutritional assessment tool in cancer patients.

Journal of cachexia, sarcopenia and muscle·2021
Same author

Structural Basis of Pore Formation in the Mannose Phosphotransferase System by Pediocin PA-1.

Applied and environmental microbiology·2021
Same journal

ODAPH (p.Arg77*) Phenotype and Onset of Ameloblast Pathology During Postsecretory Transition Demonstrated by FIB-SEM Analyses of Odaph<sup>C41*/C41*</sup> Mice.

Calcified tissue international·2026
Same journal

Cytokine Networks Reprogramming the Osteo-Immune Microenvironment in Cancer Bone Metastasis.

Calcified tissue international·2026
Same journal

Associations between controlling nutritional status and mortality in osteoporosis: evidence from NHANES, 2005-2018.

Calcified tissue international·2026
Same journal

Gut Microbiota-Derived TMAO Drives MC3T3-E1 Senescence and Osteogenic Dysfunction via cGAS-STING-NF-κB Signaling: Implications for Age-Related Bone Loss.

Calcified tissue international·2026
Same journal

Artificial Intelligence Approaches for Osteoporotic Fracture Risk Prediction Using Administrative Health Data: A Systematic Review.

Calcified tissue international·2026
Same journal

The Important Role of Polycystin in the Skeletal System.

Calcified tissue international·2026
See all related articles

Related Experiment Video

Updated: Apr 1, 2026

Stereotactic Radiosurgery for Gynecologic Cancer
10:35

Stereotactic Radiosurgery for Gynecologic Cancer

Published on: April 17, 2012

18.8K

Tumor Radiotherapy-Induced Sympathetic Hyperactivation Orchestrates Rapid Systemic Bone Loss.

Chang Wang1, Shouxiang Kuang1, Lipeng Sun1,2

  • 1Department of Orthopaedics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 9677 Jingshi Road, Jinan, 250000, Shandong, China.

Calcified Tissue International
|March 30, 2026
PubMed
Summary
This summary is machine-generated.

Radiation therapy (RT) can cause bone loss by activating the sympathetic nervous system (SNS). Targeting the SNS may help prevent fractures associated with cancer treatment.

Keywords:
Bone lossLocalized radiotherapyOsteoporosisSympathetic hyperactivationTumor radiotherapy

More Related Videos

Author Spotlight: Computing the Effects of a Local Radiofrequency Hyperthermia Intervention on Tumor Biomechanics
10:23

Author Spotlight: Computing the Effects of a Local Radiofrequency Hyperthermia Intervention on Tumor Biomechanics

Published on: December 1, 2023

1.1K
Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
06:53

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Published on: September 9, 2020

3.4K

Related Experiment Videos

Last Updated: Apr 1, 2026

Stereotactic Radiosurgery for Gynecologic Cancer
10:35

Stereotactic Radiosurgery for Gynecologic Cancer

Published on: April 17, 2012

18.8K
Author Spotlight: Computing the Effects of a Local Radiofrequency Hyperthermia Intervention on Tumor Biomechanics
10:23

Author Spotlight: Computing the Effects of a Local Radiofrequency Hyperthermia Intervention on Tumor Biomechanics

Published on: December 1, 2023

1.1K
Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
06:53

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Published on: September 9, 2020

3.4K

Area of Science:

  • Oncology
  • Bone Biology
  • Neuroscience

Background:

  • Radiation therapy (RT) is a cornerstone of cancer treatment but can lead to bone fractures.
  • The mechanisms behind RT-induced bone loss are not fully understood.
  • The sympathetic nervous system's (SNS) role in this process requires investigation.

Purpose of the Study:

  • To investigate radiation therapy-induced bone loss in an esophageal carcinoma mouse model.
  • To examine the role of the sympathetic nervous system (SNS) in RT-induced bone loss.
  • To explore the potential of targeting the SNS to mitigate bone loss and enhance antitumor effects.

Main Methods:

  • Utilized an esophageal carcinoma mouse model with localized RT (20 Gy in four fractions).
  • Administered chemical sympathectomy using 6-OHDA to assess SNS involvement.
  • Employed Micro-CT, histology, and molecular analyses to evaluate bone structure, cellular activity, and inflammatory markers.

Main Results:

  • RT increased bone norepinephrine levels and adrenergic receptor expression, indicating SNS activation.
  • Significant trabecular bone loss was observed post-RT, with sympathectomy mitigating these effects.
  • RT enhanced osteoclast activity and osteocyte apoptosis while suppressing osteoblast function; these were reversed by sympathectomy.
  • Sympathetic ablation also enhanced the antitumor effect of RT.

Conclusions:

  • Localized radiotherapy can induce systemic bone loss via excessive SNS activation.
  • Mechanisms include increased osteocyte apoptosis, enhanced osteoclastogenesis, and impaired osteoblast activity.
  • Targeting the SNS presents a potential strategy for preventing radiation-associated bone loss and may enhance cancer treatment efficacy.