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Updated: Apr 1, 2026

Engineering Antiviral Agents via Surface Plasmon Resonance
Published on: June 14, 2022
Functionalized Cyclic Beta-Amino Acid Derivatives With Antiviral Potential
Melinda Nonn1,2, Marta Denel-Bobrowska3, Balázs Volk4
1MTA TTK Lendület Artificial Transporter Research Group, Institute of Materials and Environmental Chemistry, HUN-REN Research Center for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary.
Abstract:
Selected highly functionalized cyclic beta (β)-amino acid derivatives have been synthesized according to modified and improved literature synthetic protocols and subjected to various antiviral studies. The model compounds were regio- and stereoisomers of azido-functionalized β-amino esters, orthogonally protected diamino esters, an oxirane-fused cyclic β-amino ester, 1,2,3-triazole-substituted β-amino esters, mono- and difluorinated cyclic β-amino esters, mono and dihydroxylated cyclic β-amino esters, dihydroxylated lactams, and β-amino esters with piperidine and azepane skeletons. Formed compounds have been investigated and their anti-HCMV (Human cytomegalovirus), anti-HRV8 (Human rhinovirus 8), and anti-HSV-1 (Human herpesvirus 1) activities were tested (CC50 and IC50 determinations) during screening studies.
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