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Functionalized Cyclic Beta-Amino Acid Derivatives With Antiviral Potential.

Melinda Nonn1,2, Marta Denel-Bobrowska3, Balázs Volk4

  • 1MTA TTK Lendület Artificial Transporter Research Group, Institute of Materials and Environmental Chemistry, HUN-REN Research Center for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary.

Chemmedchem
|March 30, 2026
PubMed
Summary

Highly functionalized cyclic beta-amino acid derivatives were synthesized and tested for antiviral activity against Human cytomegalovirus, Human rhinovirus 8, and Human herpesvirus 1.

Keywords:
antiviral propertycyclic amino acidsdrug designfunctionalizationstereocenter

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Area of Science:

  • Medicinal Chemistry
  • Organic Synthesis
  • Virology

Background:

  • Cyclic beta (β)-amino acids are valuable scaffolds in medicinal chemistry.
  • Developing novel antiviral agents is crucial for public health.

Purpose of the Study:

  • To synthesize diverse, highly functionalized cyclic β-amino acid derivatives.
  • To evaluate the antiviral potential of these novel compounds against key human viruses.

Main Methods:

  • Modified and improved literature synthetic protocols were employed.
  • Synthesis of various derivatives including azido-, triazole-, fluoro-, and hydroxyl-substituted compounds, as well as lactams and piperidine/azepane skeletons.
  • Antiviral activity screening including Human cytomegalovirus (HCMV), Human rhinovirus 8 (HRV8), and Human herpesvirus 1 (HSV-1) using CC50 and IC50 determinations.

Main Results:

  • A library of regio- and stereoisomers of functionalized cyclic β-amino esters and lactams was successfully synthesized.
  • Initial screening provided data on the anti-HCMV, anti-HRV8, and anti-HSV-1 activities of the synthesized compounds.

Conclusions:

  • The study established a versatile synthetic route to novel cyclic β-amino acid derivatives.
  • These compounds represent a promising starting point for the development of new antiviral therapeutics.