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Dynamic Thymic Stromal Lymphopoietin and Its Receptor Complex Expression on Skin Langerhans Cells in Response to
Martín I González-Rodríguez1, Tanja Salomaa1, Carolina Cabalin2,3,4
1Faculty of Medicine and Health Technology, Tampere University (TUNI), Tampere, Finland.
European Journal of Immunology
|March 31, 2026
Abstract:
Thymic Stromal Lymphopoietin (TSLP) regulates the skin microenvironment during type 2 inflammation. Epidermal APCs, Langerhans cells (LCs), might be the target of TSLP, but whether LCs express CD127 needed for TSLP signaling has been unclear. We found that LCs express both receptor chains needed by TSLP (CD127 and TSLPR) and upregulate the TSLPR upon Calcipotriol (MC903)-induced inflammation.

