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Persian Paradigm for Language Cortical Mapping: Development, Feasibility, and Evaluation.

Alireza Tabibkhooei1, Maryam Jalali2,3, Vahid Valinejad4,5

  • 1Skull Base Research Center, Department of Neurosurgery, Iran University of Medical Sciences, Tehran, Iran.

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|March 31, 2026
PubMed
Summary
This summary is machine-generated.

A new Persian Multi-Task Language (MTL) paradigm, integrating object naming and sentence completion, shows promise for improved intraoperative language mapping. This validated tool effectively identifies key language areas in the brain during awake surgery.

Keywords:
awake craniotomybrain mass lesiondirect cortical stimulationfunctional magnetic resonance imaginglanguage paradigm

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Area of Science:

  • Neuroscience
  • Linguistics
  • Neurosurgery

Background:

  • Current intraoperative language tasks may not fully capture complex grammatical processing.
  • Persian language cortical mapping requires enhanced tools for precision.
  • Object naming and sentence completion tasks can be integrated for improved assessment.

Purpose of the Study:

  • To develop and validate a novel Persian intraoperative language paradigm, the Multi-Task Language (MTL) task.
  • To improve the accuracy of cortical mapping for language functions in Persian speakers.
  • To assess the feasibility and effectiveness of MTL in identifying language-dominant brain regions.

Main Methods:

  • Content Validity Ratio (CVR) and Index (CVI) were used to validate task items.
  • Twenty-five patients undergoing awake surgery for brain lesions in language areas were recruited.
  • Preoperative fMRI data were collected using object naming, word generation, and the developed MTL task.

Main Results:

  • The MTL task demonstrated high content validity (CVR: 0.93 ± 0.09, CVI: 0.94 ± 0.07).
  • Significant brain activations were observed in language-related regions, including the left inferior frontal gyrus for object naming.
  • The MTL task showed robust activation in the fusiform and inferior temporal gyrus, indicating its effectiveness.

Conclusions:

  • The developed Persian MTL paradigm is valid and feasible for intraoperative language mapping.
  • The MTL task effectively activates key language areas, particularly the left inferior frontal gyrus.
  • This new paradigm offers a valuable tool for neurosurgeons operating on Persian-speaking patients.