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Updated: Apr 1, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Localized Bullous Pemphigoid Triggered by Surgical Trauma: A Case Highlighting the Koebner Phenomenon
Marwa Faik Ouahab1, Soumiya Chiheb1, Awatef Kelati1
1Dermatology Unit, Cheikh Khalifa International University Hospital, Mohammed VI University of Health Sciences, Casablanca, MAR.
Abstract:
Bullous pemphigoid (BP) is the most common autoimmune blistering disease in the elderly. Although usually spontaneous, it may be triggered by skin trauma. We report the case of a 90-year-old woman who developed localized BP along a surgical scar one month after orthopedic surgery. Lesions later spread to the trunk. Histology revealed a subepidermal blister with eosinophils, and immunofluorescence confirmed C3 deposition in addition to circulating anti-BP180 antibodies. Clinical improvement was observed following the initiation of topical corticosteroid therapy.
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