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Neuroplasticity

Neuroplasticity

Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.

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Related Experiment Video

Updated: Apr 1, 2026

Simple Generation of a High Yield Culture of Induced Neurons from Human Adult Skin Fibroblasts

Simple Generation of a High Yield Culture of Induced Neurons from Human Adult Skin Fibroblasts

Published on: February 5, 2018

Reshaping human neurons.

Jessica L Maltman^1,2, Javier González-Maeso²

¹Biomedical Sciences Graduate Program, Virginia Commonwealth University School of Medicine, Richmond, United States.

|March 31, 2026

Summary

This summary is machine-generated.

Psilocin, derived from the psychedelic psilocybin, enhances human neuron growth. Stem cell-derived neurons exhibited greater complexity and stronger connections after psilocin exposure.

Keywords:

5-HT2A receptor BDNF human human induced pluripotent stem cell derived cortical neurons neuroplasticity neuroscience psilocin psychedelics

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Area of Science:

Neuroscience
Stem Cell Biology
Pharmacology

Background:

Psilocybin is a psychedelic compound found in certain mushrooms.
Psilocin is the active metabolite responsible for psilocybin's effects.
Understanding the neurobiological impact of psychedelics is an emerging research area.

Purpose of the Study:

To investigate the effects of psilocin on human neurons derived from stem cells.
To assess changes in neuronal structure and synaptic function.

Main Methods:

Human stem cells were differentiated into neurons.
Neurons were exposed to psilocin.
Structural complexity and synaptic connections were analyzed.

Main Results:

Psilocin exposure led to increased structural complexity in human neurons.
Stronger synaptic connections were observed in treated neurons.
These findings suggest a pro-neuritogenic and synaptogenic effect of psilocin.

Conclusions:

Psilocin promotes neuronal growth and connectivity in vitro.
This research provides insights into the cellular mechanisms of psychedelic compounds.
Further studies may explore therapeutic potential in neurological disorders.