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Mitochondrial Metabolism in Breast Cancer

Qian Hu1, Zhihao Luo1, Weixi Yuan1

  • 1Pharmacy and Pharmacology, University of South China, 421001 Hengyang, Hunan, China.

Frontiers in Bioscience (Landmark Edition)
|March 31, 2026
PubMed

Insights

Mitochondrial metabolism fuels breast cancer progression and resistance. This review explores metabolic strategies and challenges for developing precision medicine to overcome therapeutic hurdles in breast cancer treatment.

Area of Science:

  • Oncology
  • Metabolic Research
  • Biochemistry

Background:

  • Breast cancer is a leading global malignancy in women.
  • Mitochondrial metabolic dysregulation is a key driver of breast cancer progression and therapeutic resistance.
  • Current therapeutic strategies face challenges due to metabolic heterogeneity and drug resistance.

Purpose of the Study:

  • To systematically review mitochondrial metabolic mechanisms in breast cancer subtypes.
  • To emphasize the spatial network regulatory functions of mitochondrial metabolism.
  • To critically evaluate combined therapeutic strategies targeting metabolic vulnerabilities.

Main Methods:

  • Systematic literature synthesis of mitochondrial metabolism in breast cancer.
  • Analysis of spatial network regulatory functions.
  • Evaluation of combined therapeutic strategies.

Main Results:

  • Mitochondrial metabolism significantly influences breast cancer subtypes and progression.
  • Metabolic heterogeneity and plasticity present major therapeutic challenges.
  • Targeting mitochondrial metabolism offers potential for novel treatments.

Conclusions:

  • Understanding mitochondrial metabolism is crucial for breast cancer treatment.
  • Novel therapeutic frameworks are needed to address metabolic challenges.
  • Precision medicine approaches targeting mitochondrial metabolism hold promise for improved outcomes.
Keywords:
breast cancerenergy metabolismmitochondriaoxidative stresstargeted therapy

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