Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Toxicity Testing in Animals01:23

Toxicity Testing in Animals

140
Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
140

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A framework for assessing practical competence in laboratory animal science (LAS): development of direct observation of procedural skills (DOPS) by the ETPLAS Working Group.

Laboratory animals·2026
Same author

Vocalisations as a potential indicator of parturition in C57BL/6J mice.

Animal welfare (South Mimms, England)·2025
Same author

A multicentre study on spontaneous in-cage activity and micro-environmental conditions of IVC housed C57BL/6J mice during consecutive cycles of bi-weekly cage-change.

PloS one·2022
Same author

Assessable learning outcomes for the EU Education and Training Framework core and Function A specific modules: Report of an ETPLAS WORKING Group.

Laboratory animals·2020

Related Experiment Video

Updated: Apr 1, 2026

Transition of Farm Pigs to Research Pigs using a Designated Checklist followed by Initiation of Clicker Training - a Refinement Initiative
07:59

Transition of Farm Pigs to Research Pigs using a Designated Checklist followed by Initiation of Clicker Training - a Refinement Initiative

Published on: August 21, 2021

6.5K

Sixty Years of Laboratory Animals

Jan-Bas Prins1

  • 1Chair of Laboratory Animals Limited, Universiteit Leiden, Leiden, Netherlands.

Laboratory Animals
|March 31, 2026
PubMed
Summary

No abstract available in PubMed .

More Related Videos

Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine
08:53

Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine

Published on: January 26, 2024

1.8K
Using Clicker Training and Social Observation to Teach Rats to Voluntarily Change Cages
08:01

Using Clicker Training and Social Observation to Teach Rats to Voluntarily Change Cages

Published on: October 25, 2018

11.0K

Related Experiment Videos

Last Updated: Apr 1, 2026

Transition of Farm Pigs to Research Pigs using a Designated Checklist followed by Initiation of Clicker Training - a Refinement Initiative
07:59

Transition of Farm Pigs to Research Pigs using a Designated Checklist followed by Initiation of Clicker Training - a Refinement Initiative

Published on: August 21, 2021

6.5K
Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine
08:53

Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine

Published on: January 26, 2024

1.8K
Using Clicker Training and Social Observation to Teach Rats to Voluntarily Change Cages
08:01

Using Clicker Training and Social Observation to Teach Rats to Voluntarily Change Cages

Published on: October 25, 2018

11.0K