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Principal Component-Based Comprehensive Physical Health Score Associates With Long-Term Death in Patients With

Guangyong Chen1, Jialing Lou2,3, Jianing Wang4

  • 1Department of Neurology The Third Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang China.

Journal of the American Heart Association
|March 31, 2026
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Summary

A new Comprehensive Physical Health Score (CPHS) effectively predicts one-year mortality after acute ischemic stroke. This score integrates 42 indicators to identify patients at higher risk due to organ dysfunction or inflammation.

Keywords:
acute ischemic strokecomprehensive physical healthdeathprincipal component analysis

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Area of Science:

  • Cardiology
  • Nephrology
  • Hepatology
  • Metabolic Medicine
  • Public Health

Background:

  • Existing clinical indicators may not fully capture patient health status.
  • Acute ischemic stroke poses significant long-term mortality risks.
  • There is a need for comprehensive health assessment tools post-stroke.

Purpose of the Study:

  • To develop and validate a Comprehensive Physical Health Score (CPHS) using Principal Component Analysis (PCA).
  • To explore the association between CPHS and 1-year mortality in patients with acute ischemic stroke.
  • To identify patient subgroups with distinct health profiles and mortality risks.

Main Methods:

  • Collected 42 clinical and laboratory indicators from acute ischemic stroke patients.
  • Constructed CPHS using PCA and Cox regression in a training cohort (n=1017) and validated in a testing cohort (n=316).
  • Utilized hierarchical clustering on principal components to define health-related subgroups.

Main Results:

  • CPHS demonstrated a significant association with 1-year mortality (P<0.001).
  • Hierarchical clustering identified 5 distinct patient clusters, ranging from healthy to high disease risk.
  • Four of the five clusters showed significantly increased 1-year mortality risk compared to the healthy cluster.

Conclusions:

  • CPHS is a reliable predictor of 1-year mortality post-acute ischemic stroke.
  • CPHS can identify markers associated with increased mortality, including liver/kidney dysfunction, cardiovascular issues, metabolic problems, and inflammation.
  • The identified patient clusters offer insights into differential mortality risks and underlying health conditions.