Predicting Catheter-Related Thrombosis in Colorectal Cancer Patients Using Clinical Features in 730 Patients

Area of Science:

• Oncology
• Vascular Medicine
• Medical Informatics

Background:

• Catheter-related thrombosis (CRT) is a significant complication for colorectal cancer patients undergoing chemotherapy.
• Current methods for predicting CRT risk are insufficient, necessitating better predictive tools.

Purpose of the Study:

• To develop and validate the TD score, a predictive model for identifying colorectal cancer patients at high risk of CRT.
• To utilize clinical parameters, specifically T stage and duration of intravenous catheter use, for risk stratification.

Main Methods:

• Retrospective analysis of 730 colorectal cancer patients with intravenous catheters.
• Development of the TD score using multivariable logistic regression on T stage and catheter duration.
• Evaluation of the TD score's performance using receiver operating characteristic (ROC) curve analysis.

Main Results:

• The TD score showed good diagnostic performance with AUCs of 0.732 (training) and 0.749 (test).
• T stage and duration of intravenous catheter use were identified as independent predictors of CRT.
• Lower T stages correlated with longer durations of non-CRT status.

Conclusions:

• The TD score shows promise for identifying patients at high risk of CRT.
• This tool may enhance risk stratification and guide prophylactic strategies for CRT.
• Further validation in diverse cohorts is recommended to confirm clinical utility across TNM stages.