Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Aneurysm at an Extremely Proximal Posterior Communicating Artery Origin Treated With Flow Diverter-Assisted Coiling: A Case Report.

Cureus·2026
Same author

Identification of tubulin gene variants in patients with dandy-walker malformation: expanding the spectrum of tubulinopathies.

Molecular cytogenetics·2026
Same author

Early recurrence of a pediatric high cervical neurenteric cyst mimicking an arachnoid cyst following cyst fenestration.

Surgical neurology international·2026
Same author

Comparing artificial intelligence and physician performance in predicting IDH mutation status in glioma.

NPJ digital medicine·2026
Same author

Lymphoplasmacyte-Rich Meningioma: Possible Formation of Intratumoral "Tertiary Lymphoid Structures".

Neuropathology : official journal of the Japanese Society of Neuropathology·2026
Same author

Synergistic antitumor effect of temozolomide and perampanel in pediatric glioma: a case report and in vitro validation using patient-derived glioma sphere cells.

Acta neuropathologica communications·2026

Related Experiment Video

Updated: Apr 1, 2026

Isolation of Adult Human Astrocyte Populations from Fresh-Frozen Cortex Using Fluorescence-Activated Nuclei Sorting
08:18

Isolation of Adult Human Astrocyte Populations from Fresh-Frozen Cortex Using Fluorescence-Activated Nuclei Sorting

Published on: April 16, 2021

3.9K

The "Azzopardi phenomenon" in high-grade astrocytoma with a PNET-like component.

Masayuki Shintaku, Tetsuo Hashiba, Masahiro Nonaka

    Clinical Neuropathology
    |March 31, 2026
    PubMed
    Summary

    The Azzopardi phenomenon, nuclear chromatin deposition on tumor blood vessels, was observed in a rare central nervous system astrocytoma. This study confirms histone co-deposition in vascular walls, a novel finding for this rare tumor vascular event.

    More Related Videos

    Modeling Astrocytoma Pathogenesis In Vitro and In Vivo Using Cortical Astrocytes or Neural Stem Cells from Conditional, Genetically Engineered Mice
    10:13

    Modeling Astrocytoma Pathogenesis In Vitro and In Vivo Using Cortical Astrocytes or Neural Stem Cells from Conditional, Genetically Engineered Mice

    Published on: August 12, 2014

    14.1K
    Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation
    09:43

    Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation

    Published on: January 14, 2014

    8.5K

    Related Experiment Videos

    Last Updated: Apr 1, 2026

    Isolation of Adult Human Astrocyte Populations from Fresh-Frozen Cortex Using Fluorescence-Activated Nuclei Sorting
    08:18

    Isolation of Adult Human Astrocyte Populations from Fresh-Frozen Cortex Using Fluorescence-Activated Nuclei Sorting

    Published on: April 16, 2021

    3.9K
    Modeling Astrocytoma Pathogenesis In Vitro and In Vivo Using Cortical Astrocytes or Neural Stem Cells from Conditional, Genetically Engineered Mice
    10:13

    Modeling Astrocytoma Pathogenesis In Vitro and In Vivo Using Cortical Astrocytes or Neural Stem Cells from Conditional, Genetically Engineered Mice

    Published on: August 12, 2014

    14.1K
    Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation
    09:43

    Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation

    Published on: January 14, 2014

    8.5K

    Area of Science:

    • Neuropathology
    • Oncology
    • Molecular Biology

    Background:

    • The Azzopardi phenomenon involves basophilic material deposition on stromal blood vessels in malignant tumors, originating from necrotizing tumor cell nuclear chromatin.
    • This phenomenon is commonly observed in small cell lung carcinoma and retinoblastoma but is rare in central nervous system (CNS) tumors.

    Purpose of the Study:

    • To report the first case of the Azzopardi phenomenon in an astrocytic tumor within the CNS.
    • To investigate the molecular composition of the deposited material, specifically the presence of histone proteins.

    Main Methods:

    • Histopathological examination of a frontal lobe high-grade astrocytoma with a primitive neuroectodermal tumor (PNET)-like component.
    • Feulgen reaction and immunohistochemistry for histone H3 to analyze the deposited material.

    Main Results:

    • The Azzopardi phenomenon was identified, characterized by basophilic material deposition on the vascular walls of small to medium-sized blood vessels.
    • The deposited material tested positive for the Feulgen reaction and was immunoreactive for histone H3.
    • Vascular smooth muscle cells were largely absent, while endothelial cells were preserved.

    Conclusions:

    • This case represents the first documented instance of the Azzopardi phenomenon in an astrocytic tumor of the CNS.
    • The study provides the first evidence of histone protein co-deposition within the vascular walls associated with the Azzopardi phenomenon.