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A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
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Comparative Safety of Potassium-Competitive Acid Blockers on the Risk of Clostridioides difficile Infection: A

Gyeongmin Lim1, Ju-Young Shin1,2,3, Da Eun Hyeon4

  • 1Department of Biohealth Regulatory Science, Sungkyunkwan University, Suwon, Republic of Korea.

The American Journal of Gastroenterology
|March 31, 2026
PubMed
Summary

Potassium-competitive acid blockers (P-CABs) showed no increased risk of Clostridium difficile infection (CDI) compared to proton pump inhibitors (PPIs) or histamine H2-receptor antagonists (H2RAs). This real-world evidence suggests P-CABs are a safe alternative for acid suppression regarding CDI risk.

Keywords:
CDIH2RAP-CABPPImulticenter study

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