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Comparison of Taurolock solution with heparin as lock solution of tunneled catheters

Hamad Jeelani1, Manzoor Ahmad Parry2, Amer Said Alameri1

  • 1Department of Nephrology, Sultan Qaboos Hospital, Salalah, Oman.

Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia
|March 31, 2026
PubMed

Insights

Citrate-taurolidine lock solution significantly reduced catheter-related blood stream infections (CRBSI) in hemodialysis patients compared to heparin. This novel solution also demonstrated comparable efficacy in preventing catheter dysfunction.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Medical Devices

Background:

  • Dialysis catheters are associated with catheter-related blood stream infections (CRBSI), increasing hospitalization, morbidity, and mortality.
  • Citrate-taurolidine lock solution presents a potential strategy to mitigate CRBSI incidence.

Purpose of the Study:

  • To evaluate the efficacy of citrate-taurolidine lock solution in reducing CRBSI.
  • To compare the incidence of CRBSI and catheter dysfunction between citrate-taurolidine and heparin lock solutions.

Main Methods:

  • Retrospective study involving 89 patients on hemodialysis for at least 6 months using tunneled catheters.
  • Comparison of TauroLock-Hep500™ (taurolidine, citrate, heparin) versus heparin lock solution for CRBSI and catheter dysfunction.

Main Results:

  • The Taurolock group (42 patients) had 3 CRBSI cases (0.39/1000 catheter days) versus 15 CRBSI cases (1.84/1000 catheter days) in the Heparin group (47 patients).
  • Catheter dysfunction rates were similar between the Taurolock and Heparin groups.
  • Two patients in the Heparin group required catheter removal, while none in the Taurolock group did.

Conclusions:

  • Citrate-taurolidine lock solution significantly reduces CRBSI incidence compared to heparin lock solution.
  • TauroLock-Hep500™ demonstrates comparable effectiveness to heparin in preventing catheter dysfunction.
  • The use of citrate-taurolidine lock solution may decrease the need for catheter removal due to complications.
Abstract

Keywords:
Catheter dysfunctioncatheter lock solutioncatheter-related bacterial infectionstaurolidinetunneled catheter

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