Quercetin and Cancer: Molecular Mechanisms and Signaling Pathway Modulation for Therapeutic Benefits

Area of Science:

• Oncology
• Molecular Biology
• Pharmacology

Background:

• Quercetin, a flavonoid abundant in fruits and vegetables, exhibits potential anticancer properties.
• Understanding its molecular mechanisms is crucial for cancer prevention and treatment strategies.

Purpose of the Study:

• To review the molecular mechanisms underlying quercetin's anticancer effects.
• To explore its impact on key signaling pathways involved in cancer progression.
• To assess its potential in combination therapies and overcoming drug resistance.

Main Methods:

• Literature review of studies on quercetin's molecular targets and anticancer activities.
• Analysis of quercetin's effects on signaling pathways like PI3K/Akt, MAPK, NF-κB, and Wnt/β-catenin.
• Evaluation of quercetin's role in apoptosis, cell cycle, metastasis, and drug resistance.

Main Results:

• Quercetin modulates critical cancer signaling pathways, inhibiting proliferation and metastasis while promoting apoptosis.
• It demonstrates synergistic effects with chemotherapy and radiotherapy, enhancing treatment efficacy.
• Quercetin shows potential in overcoming drug resistance in various cancer types.

Conclusions:

• Quercetin possesses potent anticancer properties through diverse molecular mechanisms.
• It holds promise for targeted therapeutic strategies and improved cancer management.
• Further research is needed to optimize quercetin-based interventions for specific patient populations.