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Quercetin and Cancer: Molecular Mechanisms and Signaling Pathway Modulation for Therapeutic Benefits

Md Al Amin1, Mehrukh Zehravi2, Hasna Bouhenni3

  • 1Department of Pharmacy, Faculty of Health and Life Sciences, Daffodil International University, Dhaka 1207, Bangladesh.

Current Topics in Medicinal Chemistry
|March 31, 2026
PubMed

Insights

Quercetin, a natural flavonoid, shows anticancer potential by targeting key molecular pathways. It may enhance chemotherapy and radiotherapy efficacy, offering new strategies for cancer treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Quercetin, a flavonoid abundant in fruits and vegetables, exhibits potential anticancer properties.
  • Understanding its molecular mechanisms is crucial for cancer prevention and treatment strategies.

Purpose of the Study:

  • To review the molecular mechanisms underlying quercetin's anticancer effects.
  • To explore its impact on key signaling pathways involved in cancer progression.
  • To assess its potential in combination therapies and overcoming drug resistance.

Main Methods:

  • Literature review of studies on quercetin's molecular targets and anticancer activities.
  • Analysis of quercetin's effects on signaling pathways like PI3K/Akt, MAPK, NF-κB, and Wnt/β-catenin.
  • Evaluation of quercetin's role in apoptosis, cell cycle, metastasis, and drug resistance.

Main Results:

  • Quercetin modulates critical cancer signaling pathways, inhibiting proliferation and metastasis while promoting apoptosis.
  • It demonstrates synergistic effects with chemotherapy and radiotherapy, enhancing treatment efficacy.
  • Quercetin shows potential in overcoming drug resistance in various cancer types.

Conclusions:

  • Quercetin possesses potent anticancer properties through diverse molecular mechanisms.
  • It holds promise for targeted therapeutic strategies and improved cancer management.
  • Further research is needed to optimize quercetin-based interventions for specific patient populations.
Keywords:
Quercetinapoptosiscancerclinical studies.oxidative stresssignaling pathways

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