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Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging
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Plant-based dietary patterns are associated with slower epigenetic aging.

Hyunju Kim1,2, Christina A Castellani3,4, Jiantao Ma5

  • 1Department of Epidemiology, University of Washington, Seattle, WA 98105, USA.

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Summary

Adhering to plant-based diets may slow biological aging. Higher scores on overall, provegetarian, and healthy plant-based diet indices were linked to decelerated epigenetic aging measures.

Keywords:
DNA methylationall-cause mortalityepigenetic agingmiddle-aged adultsplant-based diets

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Area of Science:

  • Nutrition Science
  • Epigenetics
  • Gerontology

Background:

  • Plant-based diets are linked to health benefits.
  • Dietary intake influences DNA methylation and epigenetic aging.
  • The association between plant-based diets and epigenetic aging in non-vegetarian populations is not well understood.

Purpose of the Study:

  • To investigate the association between different plant-based diet indices (PDI) and epigenetic aging measures.
  • To analyze data from the Atherosclerosis Risk in Communities (ARIC) Study and the National Health and Nutrition Examination Survey (NHANES).

Main Methods:

  • Four plant-based diet indices were calculated: overall PDI, provegetarian diet, healthy PDI, and unhealthy PDI.
  • Epigenetic aging was assessed using GrimAge version2, HannumAge, and PhenoAge.
  • Data from ARIC (N=2,810) and NHANES (N=2,056) were meta-analyzed using a fixed-effects model.

Main Results:

  • Higher scores in overall PDI, provegetarian diet, and healthy PDI were associated with decelerated GrimAge2 (P <0.05).
  • Higher overall PDI and provegetarian diet were associated with decelerated PhenoAge and HannumAge.
  • No significant association was found for the unhealthy PDI.

Conclusions:

  • Following diets rich in plant foods and low in animal products may slow biological aging.
  • Plant-based dietary patterns are associated with decelerated epigenetic aging.