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Updated: Apr 2, 2026

Electrophysiological Methods to Assess Peripheral Pain Block in an Anesthetized Rat
Published on: November 21, 2025
The pericapsular nerve group (PENG) block versus placebo for postoperative analgesia in elective total hip
Brigid Brown1,2, Craig Morrison1,2, Matthew G Cehic1,3
1College of Medicine and Public Health, Flinders University, Australia.
Abstract:
BackgroundThe pericapsular nerve group (PENG) block is a novel motor-sparing regional technique for hip analgesia. We hypothesized that in patients undergoing hip arthroplasty, the PENG block is more effective in reducing postoperative pain than placebo.MethodsIn this multicenter, double-blind, randomized controlled trial, patients undergoing total hip arthroplasty received spinal anesthesia and local infiltration analgesia, along with either a PENG block or a sham block. The primary outcome was dynamic pain score (numeric rating scale 0-10) measured 3 h postoperatively on day 0. Secondary outcomes included quadriceps strength, pain scores on postoperative day 1, opioid consumption, complications, length of hospital stay, and patient-reported outcome measures.DiscussionThis is the protocol of our trial in which recruitment and data collection were conducted between 28 June 2021 and 8 November 2021. The results can be found in our published work.Trial registration: Ethics approval was obtained from the Southern Area Local Health Network before recruiting the first patient. This trial was prospectively registered prior to initiation on 5 December 2020; URL: https://www.trialregister.nl/trial/9147. The study adhered to the Consolidated Standards of Reporting Trials guidelines and its extension for reporting patient-reported outcomes.
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