A strongly adhesive hyaluronic acid-based coating co-modified with polydopamine and phosphorylcholine for vascular...

As a critical intervention for severe arterial stenosis, metallic stents face limitations in long-term efficacy due to risks of late thrombosis and restenosis, while current coating technologies are often constrained by key drawbacks including limited functionality and weak interfacial adhesion. This study innovatively grafted both polydopamine (PDA) and 2-methacryloyloxyethyl phosphorylcholine (MPC) onto the molecular chain of hyaluronic acid (HA), constructing a multifunctional composite coating with robust adhesion properties for bare-metal stents. Leveraging the strong interfacial binding capacity of PDA, the coating adhesion achieved the highest grade (5B) in the ASTM D3359 standard, ensuring its long-term stability on the stent surface. Notably, the combined effect of MPC and HA not only effectively inhibited platelet adhesion and endowed the coating with excellent anticoagulant properties but also significantly promoted the specific growth of endothelial cells, efficiently advancing the endothelialization process. Through ingenious material design, this work successfully achieves the integration and optimal balance between the two critical functions of anticoagulation and pro-endothelialization in stent coatings, while concurrently addressing both thrombosis prevention and restenosis inhibition, thereby demonstrating substantial potential for enhancing the long-term efficacy of cardiovascular stents.