Related Experiment Video

Updated: Apr 2, 2026

Laparoscopic Cholecystectomy with Indocyanine Green Fluorescence: Choledochoscopic Stone Extraction and Primary Duct Suture
04:02

Laparoscopic Cholecystectomy with Indocyanine Green Fluorescence: Choledochoscopic Stone Extraction and Primary Duct Suture

Published on: November 25, 2025

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Perioperative antibiotics for mild or moderate acute cholecystitis - A systematic review and meta-analysis

Patrick Uhrenholdt Dalgaard Jensen1, Felix Graabæk1, Mai-Britt Tolstrup2

  • 1Department of Surgery, Copenhagen University Hospital - North Zealand, Hillerød, Denmark.

American Journal of Surgery
|March 31, 2026
PubMed
Abstract

Insights

Perioperative antibiotics do not reduce postoperative infections in mild-moderate acute cholecystitis. Current evidence supports omitting antibiotics for otherwise healthy patients undergoing cholecystectomy.

Area of Science:

  • Gastroenterology
  • Surgical Infectious Diseases

Background:

  • The role of perioperative antibiotics in mild-moderate acute cholecystitis remains unclear.
  • This study systematically reviews and meta-analyzes the impact of antibiotics on postoperative infectious complications in patients undergoing cholecystectomy for mild-moderate acute cholecystitis.

Conclusions:

  • Perioperative antibiotics do not appear to reduce postoperative infections in patients with mild-moderate acute cholecystitis.
  • Current evidence suggests omitting antibiotics in otherwise healthy patients undergoing cholecystectomy for this condition.
  • Further research is warranted to investigate the use of antibiotics in high-risk patient populations.
Keywords:
Acute cholecystitisAntibioticsCholecystectomyGallstone diseaseGallstonesMeta-analysisSystematic review

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