Related Experiment Video
Updated: Apr 2, 2026
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Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification
Published on: December 3, 2016
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Development of the Muscular and Skeletal System During Adolescence
Romina Ledergerber1, Moritz Schumann2, Ralf Roth3
1Department of Sport, Exercise and Health, University of Basel, Basel, Switzerland. romina.ledergerber@unibas.ch.
Advances in Experimental Medicine and Biology
|April 1, 2026
Summary
Adolescent musculoskeletal development, including muscle and bone growth, is crucial for lifelong health. Understanding factors like physical activity and genetics can optimize physical performance and prevent injuries.
Area of Science:
- Sports Science
- Developmental Biology
- Orthopedics
Background:
- Adolescence is a critical period for musculoskeletal development, influenced by mechanical, hormonal, and genetic factors.
- Muscle development and peak bone mass accrual are vital for long-term physical health and performance.
- Understanding these changes is essential for promoting lifelong musculoskeletal well-being.
Purpose of the Study:
- To comprehensively examine musculoskeletal tissue development during adolescence.
- To explore the interplay of modifiable and nonmodifiable factors influencing this development.
- To guide evidence-based strategies for optimizing musculoskeletal health and performance.
Main Methods:
- Review of key mechanisms: mechanotransduction, fiber type transitions, bone remodeling.
- Analysis of modifiable factors: physical activity, nutrition, environment.
- Consideration of nonmodifiable factors: sex, hormones, genetics.
Main Results:
- Highlights differential adaptation rates of muscle and tendon.
- Addresses sex-specific injury risks and energy availability impacts.
- Integrates findings on overuse, underload, and functional adaptations.
Conclusions:
- Adolescent musculoskeletal development is complex and multifactorial.
- Optimizing modifiable factors is key to enhancing lifelong musculoskeletal health.
- Evidence-based strategies can promote optimal physical performance and reduce injury risk.
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