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Related Experiment Video

Updated: Apr 2, 2026

Cervical Lymph Duct-Cannulated Rat Model for Assessing Lymphatic Transport from the Head and Brain
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Glymphatic System Dysfunction Associated with Inflammatory Factors in Asymptomatic Neurosyphilis.

Binbin Wang1,2, Xiaoli Cui3, Yuting Xia1

  • 1Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.

Current Medical Imaging
|April 1, 2026
PubMed
Summary
This summary is machine-generated.

Glymphatic system impairment, indicated by reduced diffusion tensor image analysis along the perivascular space (DTI-ALPS) and increased enlarged perivascular spaces (EPVS), is evident in Asymptomatic Neurosyphilis (ANS). These findings suggest potential neuroimaging biomarkers for early detection.

Keywords:
Asymptomatic neurosyphilisDTI-ALPSGlymphatic dysfunctionInflammatory factorsNormalized EPVS volume.

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Area of Science:

  • Neuroimaging
  • Neurology
  • Radiology

Background:

  • Asymptomatic Neurosyphilis (ANS) can lead to neurological complications.
  • Early detection of ANS is crucial for timely intervention.
  • Glymphatic system function is vital for brain waste clearance.

Purpose of the Study:

  • To identify glymphatic system alterations in ANS patients.
  • To correlate these alterations with inflammatory markers.
  • To explore potential early neuroimaging biomarkers for ANS.

Main Methods:

  • Prospective study comparing 33 ANS patients and 29 healthy controls (HC).
  • Magnetic Resonance Imaging (MRI) with Diffusion Tensor Image Analysis along the Perivascular Space (DTI-ALPS) and normalized Enlarged Perivascular Spaces (EPVS) volume quantification.
  • Correlation analysis between imaging metrics and cerebrospinal fluid (CSF) and peripheral blood inflammatory profiles.

Main Results:

  • ANS patients showed significantly reduced DTI-ALPS indices (1.40 vs 1.60, p=0.0001).
  • ANS patients exhibited significantly elevated normalized EPVS volume (2.28 vs 2.05, p=0.0355).
  • Exploratory correlations between EPVS, DTI-ALPS, and CSF inflammatory markers were observed but did not remain significant after FDR correction.

Conclusions:

  • This study demonstrates significant glymphatic system impairment in ANS for the first time.
  • Reduced DTI-ALPS and increased EPVS suggest diminished glymphatic activity and perivascular changes.
  • Altered DTI-ALPS and EPVS may serve as novel neuroimaging biomarkers for early ANS detection and evaluation.