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Differential pulse anoding voltammetric determination of torasemide using carbon paste electrode
Sayed I M Zayed1, Ibrahim H I Habib2
1Chemistry Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt.
Acta Chimica Slovenica
|April 1, 2026
Summary
This study details a new electrochemical method for detecting torasemide using voltammetry. The optimized technique accurately quantifies torasemide in pharmaceutical products and biological samples like urine.
Area of Science:
- Electrochemistry
- Analytical Chemistry
- Pharmaceutical Analysis
Background:
- Torasemide is a diuretic drug with clinical applications.
- Sensitive and reliable analytical methods are crucial for torasemide quality control and clinical monitoring.
- Electrochemical methods offer potential for rapid and cost-effective analysis.
Purpose of the Study:
- To investigate and optimize the electrochemical behavior of torasemide.
- To develop a sensitive voltammetric method for torasemide determination.
- To validate the method for pharmaceutical and biological sample analysis.
Main Methods:
- Electrochemical analysis of torasemide using a carbon paste electrode.
- Optimization of experimental conditions using cyclic voltammetry (CV) and differential pulse voltammetry (DPV).
- Analysis of torasemide in pharmaceutical preparations and spiked urine samples.
Main Results:
- The electrochemical oxidation of torasemide was found to be irreversible and diffusion-controlled.
- DPV analysis showed a linear response for torasemide concentrations from 0.35 to 4.13 µg/mL.
- Achieved limits of detection (LOD) and quantification (LOQ) were 0.110 µg/mL and 0.367 µg/mL, respectively.
Conclusions:
- A sensitive and efficient voltammetric method for torasemide detection was successfully developed.
- The method is suitable for quality control of torasemide in pharmaceutical formulations.
- The technique shows promise for clinical analysis and therapeutic drug monitoring.
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