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Related Experiment Video

Updated: Apr 2, 2026

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Musicality is Preserved in Neurodegeneration.

Sophia Moret1, Jordan A Galbraith1, Giulia Lorenzon1

  • 1Department of Neurology, Yale School of Medicine, New Haven, CT, USA.

The Yale Journal of Biology and Medicine
|April 1, 2026
PubMed
Summary

Musical abilities can remain intact in dementia due to preserved brain networks. This study explores how Alzheimer's disease (AD) and frontotemporal dementias (FTDs) selectively impact musicality by examining neural resilience.

Keywords:
Alzheimer’s disease (AD)atypical Alzheimer’s diseaseauditory-motor couplingautobiographical memorydefault mode network (DMN)emotional processingfrontotemporal dementia (FTD)music cognitionneurodegenerationprimary progressive aphasia (PPA)salience network

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Area of Science:

  • Neuroscience
  • Cognitive Science
  • Music Psychology

Background:

  • Dementia often impairs language, memory, and behavior.
  • Musical abilities can be preserved despite cognitive decline in dementia.
  • The neural basis for preserved musicality in dementia is not well understood.

Purpose of the Study:

  • To explain the selective preservation or impairment of musicality in Alzheimer's disease (AD) and frontotemporal dementias (FTDs).
  • To investigate the neural basis of musical resilience in dementia using a network-based perspective.

Main Methods:

  • Review of behavioral and neuroimaging evidence.
  • Analysis of case studies and neuroimaging data.
  • Examination of large-scale brain systems supporting perception, emotion, and memory.

Main Results:

  • Musicality involves interactions across perception, emotion, and memory networks.
  • Heterogeneous effects of neurodegeneration on musicality may stem from selective vulnerability of intrinsic connectivity networks.
  • In early AD, preserved salience and reward circuitry support emotional responses to music and autobiographical recall.
  • In FTDs, degeneration of anterior temporal and salience networks disrupts music interpretation, sparing lower-level auditory processing.

Conclusions:

  • Preserved musicality in dementia is linked to specific network resilience.
  • Understanding these neural mechanisms can inform music-based interventions.
  • Further research with standardized methods and longitudinal designs is needed to clarify the impact of dementia on musicality.