Related Experiment Video
Updated: Apr 2, 2026
06:23
Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota
Published on: February 15, 2019
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Berberine-gut microbiota interactions based on CiteSpace: current research status and hotspots
Yan Chen1,2,3, Tao Chen1,2,3, Shiyong Tian3
1The State Key Laboratory of Functions and Applications of Medicinal Plants, School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, Guizhou, China.
Frontiers in Microbiology
|April 1, 2026
Summary
Berberine (BBR) impacts gut microbiota, influencing metabolic and immune health. This bibliometric analysis maps BBR-gut microbiota research, revealing key themes like diabetes and inflammation, and emerging areas such as neuro-microbial crosstalk.
Area of Science:
- Microbiology
- Pharmacology
- Metabolomics
Background:
- The gut microbiota plays a crucial role in host metabolic and immune homeostasis.
- Berberine (BBR), derived from Coptis chinensis, can improve metabolic disorders by altering the gut microbial community.
- Limited systematic reviews exist on the mechanisms of BBR-gut microbiota interactions.
Purpose of the Study:
- To conduct a bibliometric analysis of research on berberine-gut microbiota interactions.
- To identify publication trends, collaboration networks, and key research themes.
- To highlight emerging research frontiers in this field.
Main Methods:
- Bibliometric analysis of 426 articles from Web of Science Core Collection and CNKI (2005-2025).
- Utilized CiteSpace software for analysis.
- Included publication trends, country/author collaboration, keyword co-occurrence, burst detection, and document co-citation analysis.
Main Results:
- A consistent rise in annual publications, with China as the leading contributor.
- Limited collaboration among research groups was observed.
- Key research clusters include diabetes, inflammation, bile acid metabolism, and colorectal cancer.
- Emerging hotspots: depression, fecal microbiota transplantation (FMT), bile acids, and ulcerative colitis.
- Foundational themes: microbial metabolites and metabolic-immune crosstalk.
Conclusions:
- This study provides a comprehensive overview of the berberine-gut microbiota research landscape.
- Identified emerging areas like neuro-microbial crosstalk, FMT-based therapies, and metabolic-immune mechanisms.
- Offers valuable insights for future research directions and collaborations.
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