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Circulating Red Cell and Platelet Microparticles in Pediatric Non-transfusion Dependent Beta-thalassemia: A Case

Bothaina El-Domiaty¹, Moustafa Salama¹, Neveen Lewis Mikhael²

¹Pediatrics Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Oman Medical Journal

|April 1, 2026

Abstract

Objectives:

To evaluate the levels of circulating erythrocyte-derived microparticles (EMPs) and platelet-derived microparticles (PMPs)in children with non-transfusion-dependent beta-thalassemia (NTDT), and explore their contribution to hypercoagulability.

Methods:

This case-control study included 50 children diagnosed with NTDT and 50 age- and sex-matched healthy controls. The children were recruited from the hematology/oncology unit of Alexandria University Children's Hospital, Egypt from November 2022 to May 2023.

Results:

The percentage of EMPs and PMPs was significantly higher in NTDT patients compared with healthy controls. Serum B-type natriuretic peptide was higher in NTDT patients compared to controls; however, it didn't reach a statistical significance.

Conclusions:

The significantly higher levels of EMPs and PMPs in NTDT patients may contribute to the hypercoagulable state associated with the disease. Measurement of proB-type natriuretic peptide, though not statistically significant in this cohort, may hold potential as an early biomarker for pulmonary hypertension in NTDT patients, for which larger prospective studies are recommended.

Keywords:

Egypt Erythrocytes Microparticles Pediatric Platelet Activation beta-Thalassemia

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