Related Experiment Video
Updated: Jun 3, 2026
07:56
Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats
Published on: April 21, 2017
11.2K
Global insights into pediatric ischemic stroke: a bibliometric and visualization analysis.
Yangyang Zhou1, Xiaoye Huang2, Kai Cai2
1Department of Neurosurgery, Shenzhen Children's Hospital, Shenzhen, China.
Frontiers in Medicine
|April 1, 2026
Summary
Research on pediatric ischemic stroke (IS) shows a rising trend, with key hotspots in causes, treatments, and collaboration. Enhanced global partnerships are crucial for advancing pediatric IS research and care.
Area of Science:
- Neurology
- Pediatrics
- Bibliometrics
Background:
- Pediatric ischemic stroke (IS) is a serious condition impacting children's long-term health due to neurological issues.
- Understanding research trends is vital for improving diagnosis and treatment of IS in children.
Purpose of the Study:
- To conduct a comprehensive bibliometric analysis of pediatric IS research from 2000 to 2024.
- To identify key research trends, influential publications, and collaboration patterns in pediatric IS.
Main Methods:
- Publications on pediatric IS were gathered from Web of Science Core Collection and PubMed.
- Bibliometric analysis and visualization were performed using VOSviewer, CiteSpace, and the Bibliometrix R package.
Main Results:
- Publication trends for pediatric IS have steadily increased since 2000.
- The United States leads in research output and collaboration; Hospital for Sick Children (Canada) is a leading institution.
- Research focuses on etiology, clinical interventions, and multidisciplinary management of pediatric IS.
Conclusions:
- Bibliometric analysis reveals evolving research landscape in pediatric IS.
- Increased international and institutional collaboration is recommended to advance pediatric IS knowledge and resource sharing.
More Related Videos
04:32Measuring Post-Stroke Cerebral Edema, Infarct Zone and Blood-Brain Barrier Breakdown in a Single Set of Rodent Brain Samples
Published on: October 23, 2020
8.9K
05:52Early Pathological and Magnetic Resonance Detection of Cerebral Injury Using a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy
Published on: October 28, 2022
1.1K
Related Concept Videos
01:29Stroke: Introduction and Types
A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...
01:15Ischemic Stroke l: Introduction
Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
01:15Ischemic Stroke ll: Pathophysiology
An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
01:17Hemorrhagic Stroke l: Introduction
A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
01:29Hemorrhagic Stroke ll: Pathophysiology
A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
01:26Transient Ischemic Attack l: Introduction
A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...