Selective Functionalization of 1-substituted-3-arylquinoxalin-2(1H)-ones via C-H activation
Prashant Kumar1, Priya1, Sriparna Dutta2
1Department of Chemistry, SRM University Delhi-NCR Sonepat Haryana-131029 India prashant.kumar@srmuniversity.ac.in prashanttomar972@gmail.com.
None:
Over the past few decades, transition-metal-catalyzed selective functionalization of C-H bonds has fascinated the scientific community by offering striking advantages in comparison to traditional methods, such as high atom economy, a reduced number of reaction steps, and milder reaction conditions. Moreover, directing-group-assisted C-H activation enhances the significance of transition-metal catalysis further by enabling precise and site-selective functionalization. This mini-review outlines recent advancements in the imine-directed, transition-metal-catalyzed selective functionalization of N-alkyl-3-phenylquinoxalin-2(1H)-ones, highlighting C-C, C-O, C-X (X = Cl, Br, and I), C-S, and C-Se bond formation reactions and mechanistic aspects of these transformations.
Related Concept Videos
ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH3
Nucleophilic Aromatic Substitution of Aryldiazonium Salts: Aromatic SN1
In the Sandmeyer reaction, for example, the diazonio group is replaced by a chloro, bromo,...
Nucleophilic Aromatic Substitution: Elimination–Addition
Diazonium Group Substitution: –OH and –H
Cycloaddition Reactions: MO Requirements for Photochemical Activation
Nucleophilic Aromatic Substitution: Addition–Elimination (SNAr)
The reaction begins with an attack of the nucleophile on the carbon that holds the leaving group. This results in the delocalization of the π electrons over the ring carbons. The resonance interaction between...


