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Published on: February 16, 2024
Endocervical gastric-type AIS: a rare histologic finding that further supports the hypothesis of a pyloric-type
Michele Paudice1,2, Veronica Parrella3, Giulia Scaglione4
1Department of Integrated Diagnostic and Surgical Sciences (DISC), University of Genoa, Genoa, Italy.
Background:
Gastric-type adenocarcinoma in situ (gAIS) is a rare, HPV-independent precursor of cervical adenocarcinoma with incompletely defined histogenesis.
Aims:
To report a case of gAIS and its association with pyloric-type gastric metaplasia.
Materials And Methods:
A case of gAIS in a 70-year-old woman with atypical glandular cells (Pap test) and negative HPV molecular testing was evaluated histologically and immunohistochemically.
Results:
Conization revealed atypical glandular epithelium. The lesion was CK7/CDX2 positive, with mutant-type p53 expression, and negative for CK20, PAX8 and p16. Adjacent pyloric-type gastric metaplasia was identified.
Discussion:
The association with pyloric-type metaplasia supports a possible metaplastic origin and highlights diagnostic challenges in limited samples.
Conclusion:
This case supports a possible link between gAIS and pyloric-type gastric metaplasia, underscoring the importance of accurate recognition in HPV-independent cervical lesions.
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