The ARTIST Post-Market Study: Evaluating a High G' Hyaluronic Acid (HA) Injectable for Chin Combined With Midface HA...

A novel hyaluronic acid (HA) injectable (Restylane Shaype, HA_SHA) with high strength/firmness and enhanced HA concentration, optimized for lower face shaping has been developed.

This prospective, 8-week, multicenter, post-market study evaluated three treatment algorithms, i.e., the Shayping Technique, for subjects with multiple aesthetic needs, including HA_SHA for chin augmentation alone/in combination with treatments for the lower face and midface with HA_DEF (Restylane Defyne) and HA_LYF (Restylane Lyft Lidocaine).

Subjects ≥ 18 years were assigned to one of the following treatments: Group 1: HA_SHA (chin); Group 2: HA_SHA (chin) and HA_DEF (marionette line areas laterally to the chin); Group 3: HA_SHA (chin), HA_DEF (marionette line areas laterally to the chin), and HA_LYF (midface and/or nasolabial fold [NLF, piriform fossa] and/or jawline). Assessments included Global Aesthetic Improvement Scale (GAIS), subject and investigator satisfaction, and collection of adverse events (AEs).

The GAIS responder rate ("improved," "much improved," or "very much improved") was 100% in all groups at Week 8 (primary endpoint) and Week 4 as assessed by the investigator and by subject self-assessment at Weeks 4 and 8. Overall subject and investigator satisfaction with treatment was high, and the safety profile for all product combinations was favorable, with no unexpected AEs.

Treatment with HA_SHA for chin augmentation alone/in combination with HA_DEF and HA_LYF for comprehensive lower face and midface lift was safe and effective, with 100% aesthetic improvement at 8 weeks post-injection. The Shayping Technique provides standardized guidance for practitioners to perform safe injections and achieve optimal aesthetic outcomes.