Related Experiment Video

Updated: May 20, 2026

Stereological and Flow Cytometry Characterization of Leukocyte Subpopulations in Models of Transient or Permanent Cerebral Ischemia
12:42

Stereological and Flow Cytometry Characterization of Leukocyte Subpopulations in Models of Transient or Permanent Cerebral Ischemia

Published on: December 28, 2014

16.2K

Platelet-to-lymphocyte ratio as an inflammatory marker associated with stroke severity in acute ischemic stroke: a

Sathiyanarayanan Janakiraman1, Kawiraj N1, C Pravin Coumar1

  • 1Department of General Medicine, Sri ManakulaVinayagar Medical College and Hospital, Kalitheerthalkuppam, Puducherry, India.

The International Journal of Neuroscience
|April 1, 2026
PubMed

Stroke is a major cause of disability and mortality in India, occurring as ischemic or hemorrhagic. Platelets drive thrombosis and inflammation, while lymphocytes exert anti-inflammatory effects. The platelet-to-lymphocyte ratio (PLR) reflects these opposing mechanisms. This study evaluated PLR in acute ischemic stroke and its correlation with 'National Institutes of Health Stroke Scale (NIHSS)'. A prospective observational study was conducted at Sri ManakulaVinayagar Medical College, Puducherry (January-December 2023). Sixty-four acute ischemic stroke patients were evaluated. NIHSS was recorded, and PLR calculated from complete blood counts at admission and after five days. Most patients were above 45 years (87.5%) and male (60.9%). Dyslipidemia (65.6%) and diabetes mellitus (64.1%) were the commonest comorbidities. The middle cerebral artery was most frequently affected (48.4%). PLR showed a significant positive correlation with NIHSS at admission and day five. PLR is a simple, cost-effective marker for predicting stroke severity and outcomes, aiding management decisions.

Keywords:
Strokeinflammationischemic strokelymphocyteplateletplatelet-to-lymphocyte ratioprognosis

More Related Videos

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain12:14

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain

Published on: February 12, 2016

36.5K
Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model08:22

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model

Published on: June 20, 2025

574

Related Concept Videos

Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...