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Updated: Apr 2, 2026

Synthesis of Esters Via a Greener Steglich Esterification in Acetonitrile
Published on: October 30, 2018
DNA-Compatible Strecker Reaction for the Synthesis of α-Aminonitriles
Danila Ryzhikh1, Gyuhwa Cho1, Jihoon Lee2
1KNU G-LAMP Project Group, KNU Institute of Basic Sciences, Department of Chemistry, Kyungpook National University, Daegu 41566, Republic of Korea.
None:
We report a DNA-compatible synthesis of α-aminonitriles via the Strecker reaction. Systematic optimization of reaction conditions and evaluation of a broad range of aldehydes and aromatic amines revealed high functional-group tolerance, with 68% of the examined substrates affording ≥ 70% conversion. The transformation proceeds under mild conditions that preserve DNA integrity, enabling multicycle split-and-pool library synthesis. This method expands the repertoire of DNA-compatible multicomponent reactions and enables the incorporation of α-aminonitrile scaffolds into DEL platforms.
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