Related Experiment Video

Updated: Apr 2, 2026

Author Spotlight: Developing a Rat Model for Weight-Bearing Intervention to Investigate Osteonecrosis of the Femoral Head
05:55

Author Spotlight: Developing a Rat Model for Weight-Bearing Intervention to Investigate Osteonecrosis of the Femoral Head

Published on: September 27, 2024

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ANK1 and EPB41 Variants and The Risk of Glucocorticoid-Induced Osteonecrosis

Shengbao Chen1, Xianmin Zhu2, Zhongzhong Chen3

  • 1Department of Orthopaedic Surgery and Institute of Microsurgery on Extremities, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, National Center for Orthopaedics, Shanghai, China.

Arthritis & Rheumatology (Hoboken, N.J.)
|April 1, 2026
PubMed
Summary

Rare variants in ANK1 and EPB41 genes are linked to steroid-induced osteonecrosis of the femoral head (SONFH). These genetic factors compromise red blood cell integrity, increasing SONFH risk when combined with steroid use.

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