Diagnostic Performance of 68 Ga-SSTR PET/CT and Contrast-Enhanced CT for Preoperative Lymph Node Staging in Duodenal...

Accurate preoperative lymph node (LN) staging is critical for determining optimal surgical strategies in duodenal and pancreatic neuroendocrine neoplasms (DP-NENs). While both gallium-68-labeled somatostatin receptor (SSTR) PET/CT and contrast-enhanced CT (ceCT) offer distinct advantages for LN assessment, their comparative diagnostic accuracy remains undefined. We aimed to systematically evaluate and directly compare the diagnostic performance of 68 Ga-SSTR PET/CT and ceCT against pathologic gold standards in DP-NENs.

We retrospectively analyzed 521 LNs from 136 regional stations in 42 DP-NEN patients who underwent preoperative 68 Ga-SSTR PET/CT and ceCT followed by surgical LN dissection at 2 medical centers. Pathologic validation revealed comparable detection rates for 68 Ga-SSTR PET/CT and ceCT at the patient and regional levels. However, at the individual lesion level, 68 Ga-SSTR PET/CT demonstrated significantly higher sensitivity (67.6% vs. 26.4%, P =0.008) and accuracy (96.5% vs. 94.0%). In patients with small DP-NENs (≤2 cm), 68 Ga-SSTR PET/CT also exhibited superior lesion-level sensitivity (52.6% vs. 26.3%, P =0.004) and accuracy (94.0% vs. 93.5%). The size of the metastatic deposit within LNs significantly influenced 68 Ga-SSTR PET/CT detection ( P =0.036), whereas the overall LN size was associated with ceCT performance ( P =0.048).

68 Ga-SSTR PET/CT provided superior detection of lymph node metastases (LNM) compared with ceCT. Preoperative integration of 68 Ga-SSTR PET/CT, particularly in conjunction with ceCT, might enhance staging accuracy, guiding less aggressive surgical approaches and avoiding nontargeted lymphadenectomy, especially in patients with small DP-NENs.